Changes in the complement system in membranoproliferative glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Classical complement pathway activation in membranoproliferative glomerulonephritis.
Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results compared with the levels in normal subjects. Although C3 and C5 concentration...
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The complement system is an essential part of innate immunity by its role in protection against infections, but it is also involved in waste disposal and in modulating the adaptive immune response. Under physiological conditions complement activation is effectively regulated to restrain it to the required targets and extent, and to prevent collateral host tissue damage. An imbalance between com...
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Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive renal disease that is diagnosed on the basis of renal histological features. Several MPGN subtypes have been defined by the localization and composition of glomerular deposits (electron dense, Ig and C3). MPGN II or dense deposit disease (DDD) which is defined by the occurrence of electron dense deposits within the lamina ...
متن کاملMembranoproliferative Glomerulonephritis
Membranoproliferative glomerulonephritis (MPGN) refers to glomerular pathology in which there is thickening of the capillary wall together with mesangial expansion. In this article we firstly review the pathological features of MPGN and discuss how advances in our understanding of the association between abnormalities in the regulation of complement and MPGN have revealed limitations in the his...
متن کاملMembranoproliferative glomerulonephritis.
Glomerulonephritis (GN) encompasses a wide variety of primary and secondary diseases that cause injury to the functioning unit of the kidney, the glomerulus. The many classifications of GN sometimes lead to confusion. This case study describes an individual with membranoproliferative GN and includes discussion of classification, treatment, and prognosis of this disease.
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ژورنال
عنوان ژورنال: Terapevticheskii arkhiv
سال: 2017
ISSN: 0040-3660
DOI: 10.17116/terarkh201789669-77